Ethyl 1-(4-hydroxybenzyl)cyclobutanecarboxylate

Ethyl 1-(4-hydroxybenzyl)cyclobutanecarboxylate - Names and Identifiers

Name	Ethyl1-(4-Hydroxybenzyl)Cyclobutane-1-Carboxylate
Synonyms	Ethyl 1-(4-hydroxybenzyl)cyclobutanecarboxylate Ethyl1-(4-Hydroxybenzyl)Cyclobutane-1-Carboxylate ETHYL1-(4-HYDROXYBENZYL)CYCLOBUTANE-1-CARBOXYLATE Cyclobutanecarboxylic acid, 1-[(4-hydroxyphenyl)methyl]-, ethyl ester
CAS	114672-06-9

Ethyl 1-(4-hydroxybenzyl)cyclobutanecarboxylate - Physico-chemical Properties

Molecular Formula	C14H18O3
Molar Mass	234.29
Density	1.169±0.06 g/cm3(Predicted)
Boling Point	349.6±15.0 °C(Predicted)
pKa	10.10±0.15(Predicted)
Storage Condition	Room Temprature

Ethyl 1-(4-hydroxybenzyl)cyclobutanecarboxylate - Introduction

Ethyl 4-hydroxybenzylcyclobutane-1-carboxylate (4-HOBCA) is an organic compound with the chemical formula C13H18O3. The following is a brief introduction to the properties, uses, preparation methods and safety information of the compound:

Nature:
-Appearance: 4-HOBCA is usually a colorless to pale yellow oily liquid.
-Solubility: Soluble in organic solvents such as alcohols and ethers, slightly soluble in water.
-Melting point and boiling point: The melting point is about 40-42°C, and the boiling point is about 298-299°C.
-Chemical properties: 4-HOBCA is an anhydride compound, which can react with acid or base to generate the corresponding salt.

Use:
- 4-HOBCA is widely used in organic synthesis, especially as an important intermediate compound.
-It plays a key role in the field of medicine and can be used in the production of anti-inflammatory drugs, narcotic drugs and antibiotics.

Method:
The preparation method of 4-HOBCA can be achieved by the following steps:
1. First, benzyl cyclobutane -1-carboxylic acid ethyl ester is reacted with 1.0 equivalent of sodium hydroxide (NaOH) in alcohol.
2. Chloroformate is added as a catalyst in the reaction, and the reaction time and temperature should be controlled within a suitable range.
3. After completion of the reaction, 4-HOBCA was obtained by acidification and concentration.

Safety Information:
- 4-HOBCA is a chemical and should be handled with caution and in accordance with safe operation guidelines.
-It may be irritating to the skin, eyes and mucous membranes, and direct contact should be avoided when using.
-Use appropriate personal protective equipment such as lab gloves, protective goggles and face shields when handling.
-When using, storing and disposing, please refer to relevant regulations and safety guidelines to ensure personal safety and environmental protection.

Last Update：2024-04-09 21:01:54